Expression of human adenosine deaminase in nonhuman primates after retrovirus-mediated gene transfer
نویسندگان
چکیده
Primate bone marrow cells were infected with a retroviral vector carrying the genes for human adenosine deaminase (h-ADA) and bacterial neomycin resistance (neor). The infected cells were infused back into the lethally irradiated donor animals. Several monkeys fully reconstituted and were shown to express the h-ADA and neor genes at low levels in their recirculating hematopoietic cells for short periods of time.
منابع مشابه
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 166 شماره
صفحات -
تاریخ انتشار 1987